Monday, March 15, 2010

Mega benefits from Mega science

India spends over $2.5bn on science and technology by participating and contributing towards the so called Mega Projects on the planet. Additionally we produce 5000 science doctorates per year, a vast resource. This would indeed imply a terra firma for harvesting rich rewards. Reminding ourselves that where there is basic science there is industrial growth and where there is industrial growth there is basic science, let's look deeper.
What is Mega Science and what are Mega Projects
In the early days Mega Science was defined as "big money, big machines" and was used to refer mainly to unique experimental apparatus like particle accelerators, ground or space telescopes like the Hubble Space Telescope, and Space Exploration (ESA and ISS). However this definition has evolved since and now applies to complex research where not only very large sums of money, necessitating partnerships between different countries, are a requirement but also large teams of competent researchers, thus needing cross-border co-operations between countries and participating institutes often over long periods of time. Consequently an efficient technical coordination and streamlined resource management becomes mandatory over the project duration. The evolution of cross disciplinary competence is a natural outcome throughout the life of such a Mega Project.
Some examples of such research programs are found in studies of the Human Genome, Oceanographic studies, Weather Forecasting and Biodiversity. International facilities as those for Antiproton and Ion Research (FAIR), European Laboratory for Particle Physics (CERN), International Thermo Nuclear Experiment Reactor (ITER), and Relativistic Heavy Ion Collider (RHIC) amongst others house Mega Science and Mega Projects. In these large international collaborations India is well represented. Her role in the local Large Hadron Collider experimental program at CERN, showed the entire world that we can participate in giant endeavours spanning the globe and have the technological wherewithal in both hardware and software technologies. Nonetheless no single country can keep its scientific and technological progress at par with international standards without the assistance of other countries.
As Betrand Russel once said: "almost everything that distinguishes the modern world from earlier centuries is attributable to the progress in science". This desire to extend our knowledge and go beyond the present limits is part of our heritage and cultural life. Benefits follow naturally.
A Mega Project provides opportunities and platforms to work together facilitating first hand experiencing of work ethic and scientific and technological developments in other countries. By allowing access to sophisticated research facilities, it permits an interaction between colleagues at all levels thus filling the lacuna of know-how and knowledge resulting in an accelerated pace of development.
Coming to the point of education and outreach, nothing can beat the 'Black Hole' phenomena that suddenly glamorized particle physics all over the world, particularly in India. This is one example where a Mega science project caught the imagination (literally - remember the imaginary end of the world on Sept 10th 2008) and popularized science in the country. Little known CERN Laboratory in Geneva became the buzzword for all of September 2008 and thereafter. Several Institutes, students and teaching staff from remote corners of the country became interested to forge partnerships, sending interns and becoming part of the phenomena. As a very miniscule part of all this I had the proud privilege of hosting 11 Indian students for the very first time this summer at CERN. These students from the field of engineering were working as interns in various technological fields and have created a proud impact both at CERN, and in the country.
We absolutely need to continue and take these partnerships to another dimension namely bringing the large science into each classroom and into the common man's life.
What are commercial benefits from Mega Science projects?
As an incubator for invention and for the development of new products, services, ideas and organizations, cross-disciplinary frontier research results in ambitious initiatives. Did anyone predict the colossal impact the World Wide Web, developed at CERN for sharing scientific data among collaborators? To propose and defend a bold idea is only possible within a framework of likeminded competent people which is provided by a Mega Project.
Some of direct spin offs can be seen for example in medicine: CCD imagers designed for the Hubble Space Telescope now guide breast biopsy procedures reducing surgery costs by 75%. Adaptive optics from advance Telescopes help map the eye retina and are leading to improved surgery and corrective lenses. PET (Positron Emission Tomography) is a very important technique for localizing and studying certain types of cancer by using antimatter. Detectors developed at CERN replace film with digital detectors and digital X-rays allow radiologists to gather high-quality image and expose patient to much lower doses of X-rays. Mammograms are low-dose X-rays for the detection of breast cancer and around 9000 of the 17000 accelerators operating in the world today are used for medicine and therapy. The World Wide Web provides seamless access to information that is stored in many millions of different geographical locations. The Grid is an infrastructure that provides seamless access to computing power and data storage capacity distributed over the globe. The weather Grid system comprises thousands of interlinked computers helping to process complex weather data to improve forecasting. Distributed computing allows remotely located PCs work on small sections of huge amounts of data. Money and human lives can and are being saved using accurate weather forecasting. The list of spin-offs is endless.
In a nutshell, significant returns on financial investments are made in Mega Projects. Financial multipliers in the order of 2.7 for ESA and 3.7 for CERN clearly indicate that money invested in mega science generates two to four fold returns for the investors and industry at large.
International collaborations at CERN for example, have been very successful in technology transfer, where research developments have led to applications in other fields. A pioneering study carried out at CERN into the effect of the experience that technological industrial partners gain through working in the arena of Mega Science revealed variety of outcomes which included technological learning, the development of new products and markets, and impact on the firm's organization. Together, these findings implied ways in which CERN - and by implication other Mega Science Centers and Projects - could further boost technology transfer into spill-over benefits for industrial knowledge and enhance their contribution to industrial R&D and innovation. Important signs of development of new businesses, products and services, and increased internationalization of sales and marketing operations (38% new products and 60% new customers) have resulted after the international exposure and direct contractual relationship.
Urgent progress is needed in combining international networking and critical mass, stimulating reform of national laboratories, in putting together science and research, advanced academic and technical training, engineering and industry, in joining successfully the efforts and investments of national research agencies, laboratories and universities, in closing the gap between students and professionals at the most demanding international level. By giving priority to science, we look forward to celebrating and pushing technical ingenuity well beyond its limits, building a monument of human civilization and to the power of knowledge - called India! After all 'imagination is more important than knowledge' - Einstein!

Internet nominated for '2010 Nobel Peace Prize'


It's official. The Internet, which has virtually revolutionised the world, has been nominated for the '2010 Nobel Peace Prize'.

The Internet was proposed by the Italian edition of the popular Wired magazine for promoting "dialogue, debate and consensus through communication" as well as democracy, the media reported.

Premier endorsers of Internet for Nobel Peace Prize nomination include 2003 Nobel laureate Shirin Ebadi and famous Italian surgeon, known for his contributions to breast cancer treatments, Umberto Veronesi.

Wired Italy has also launched a dedicated campaign, 'Internet for Peace', which will carry on till September 2010, featuring different stories and experiences of those who with the web have tried to do something concrete to promote peace and harmony in the world.

"We have to look at the Internet as a huge community where men and women from all over the world and with very different religious views can communicate and sympathise,
spreading a new culture centred on collaboration and sharing of knowledge that breaks all barriers.

"For this reason, the Internet can be considered the first weapon of mass construction, which we can deploy to destroy hate and conflict and propagate peace and democracy.

"What happened in Iran after the latest election and the role the web played in spreading information that would otherwise have been censored, are only the newest examples of how the Internet can become a weapon of global hope," Riccardo

Friday, March 12, 2010

Each Day of a Week Dedicated to a Particular Hindu God

In Hinduism, each day of a week is dedicated to a particular god in the Hindu pantheon. Apart from the special Vratas and Upvaas, many Hindus also fast on a particular day in a week. Each day in a week has a specialty and there are numerous folklores associated with the fasting observed on the days of a week.


Sunday

Sunday is dedicated to Lord Surya (Sun God). Those who undertake fast (upvaas) on the day only take a single meal. Oil and salt is avoided. Red is the color of the day and red flowers are offered to Surya. (more details)

Monday

Monday is dedicated to Lord Shiva. It is said that Lord Shiva is easily pleased. Therefore many people observe Upvaas on Monday. Those devotees observing fast only eat food once. People visit Lord Shiva shrines and conduct pujas, especially, Ardhanarishwara puja. The mantra ‘Om Namah Shivaya’ is chanted continuously. Siva devotees also read Shiva Purana. Unmarried women observe the Vrat to get good husbands. Others observe it for a happy and prosperous family life. (more details)

Tuesday

Tuesday is dedicated to Lord Ganesha, Durga, Goddess Kali and Lord Hanuman. Most devotees visit Devi and Hanuman shrines. Those people who fast avoid taking food containing salt at night. (more details)

Wednesday

Wednesday is dedicated to planet Mercury and Lord Vithal, an incarnation of Krishna. Green color leaves, especially Tulsi leaves, are used in Pujas. The day is highly auspicious for starting new ventures and it is believed that those who observe the Vrat are bound to get blessed with fortunes. People also give alms on the day. (more details)

Thursday

Thursday is dedicated to Lord Vishnu and his incarnations. Pujas are conducted using milk, ghee etc. Food is only eaten once and that too containing milk products. People read Srimad Bhagavad Purana on the day. (more details)

Friday

Friday is dedicated to Mother Goddess – Mahalakshmi, Santhosi Ma, Annapuraneshwari and Durga. Sweets are distributed on the day. Those devotees observing the Vrat make it a point to eat at night. (more details)

Saturday

Saturday is dedicated to alleviating the bad influence of Lord Shani. The Vrat on this day is mainly observed by those people who believe in Hindu astrology. Black is the color of the day and people visit Shani shrine or Navagraha shrines. Food is only consumed once on the day. (more details)

It must be noted here that the deity worshipped on a particular day might vary from region to region and community to community. The result of all upvaas or fast depends on the person. It is good, if all the members in the family can undertake a Vrata together.

Miracles do happen by observing a particular Vrata and the greatest miracle is Brahman realization. All rituals and observances are path towards understanding the Supreme Soul and this will automatically alleviate all sufferings.

UGADI - TELUGU NEW YEAR'S DAY

Ugadi is the New Year's Day for the people of Andhra Pradesh and also for the Telugu people all over the world. Those who live north of the Vindhya hills observe it as "Barhaspatyamana". People living to the south of the Vindhya hills observe it as "Sauramana" or "Chandramana".

A Unique Ritual: There is a peculiarity about the practices of the various sects of Brahmins; one who is not conversant with them finds it difficult to understand their meaning. Even though they are all Brahmins certain differences in their lineage may be traced among them. These become manifest in their distinctive calendars where the dates and months vary. Some have calculations according to the solar system, and others according to the lunar system; with the result that despite all being Brahmins the New Year differs among different sects. Thus there is a Telugu New Year's Day, a Tamil New Year's Day, and a New Year's distinct from these in the almanac of North India.



According to Chandramana, Ugadi is celebrated on the bright fortnight ('Shukla Paksha') of the first month ('Chaitra Masa') in the first season of the year i.e. Spring ('Vasanta-Ritu'). As all these important elements are present, this day has special significance marking the commencement of a New Year.

Significance: It is believed that the creator of the Hindu pantheon Lord Brahma started creation on this day - "Chaitra Suddha Padhyami" or the Ugadi day. Also the calculations of the great Indian Mathematician Bhaskaracharya proclaim the Ugadi day as the beginning of the New Year, New month and New day. The onset of spring also marks a beginning of new life with plants acquiring new life, shoots and leaves. The vibrancy of life and verdant fields, meadows full of colourful blossoms signify growth, prosperity and well-being.



With the coming of Ugadi, the naturally perfumed Jasmine's spread a sweet fragrance, which is perhaps unmatched by any other in nature's own creation. While large garlands of Jasmine are offered to Gods in homes and temples, Jasmine flowers woven in clusters adorn the braids of women.

Predictions Of The Year: Ugadi marks the beginning of a new Hindu lunar calendar with a change in the moon's orbit. On this day, people chant mantras and the pundits make predictions for the coming year. Traditionally, the "Panchangasravanam" or listening to the yearly calendar was done at the temples or at the Town square but with the onset of modern technology, one can get to hear the priest-scholar on television sets right in one's living room.

Preparing For The Occasion: Preparations for the festival begin a week ahead. Houses are given a thorough wash. Shopping for new clothes and buying other items that go with the requirements of the festival are done with a lot of excitement.


Ugadi is celebrated with festive fervour in the states of Maharashtra, Karnataka and Andhra Pradesh. While it is called Ugadi in Andhara and Karnataka, in Maharashtra it is known as "Gudipadava".


On Ugadi day, people wake up before the break of dawn and take a head bath after, which they decorate, the entrance of their houses with fresh mango leaves. The green mango leaves tied to the doorway signify a good crop and general well being. It is noteworthy that one uses mango leaves and coconuts (as in a 'Kalasam', to initiate any puja) only on auspicious occasions to propitiate gods.


People also splash fresh cow dung water on the ground in front of their house and draw colourful floral designs. This is a common sight in every household. People perform the ritualistic worship to God invoking his blessings before they start off with the New Year. They pray for their health, wealth and prosperity and success in business too. Ugadi is also the most auspicious time to start new ventures.


Special Delicacies:It is a season for raw mangoes spreading its aroma in the air and the fully blossomed Neem tree that makes the air healthy. Also, jaggery made with fresh crop of sugarcane adds a renewed flavour to the typical dishes associated with Ugadi.


"Ugadi Pachchadi" is one such dish that has become synonymous with Ugadi. It is made of new jaggery, raw mango pieces, Neem flowers and new tamarind. The inner significance of this preparation is to indicate that life is a mixture of good and bad, joy and sorrow and all of them have to be treated alike.


All experiences have to be treated with equanimity. Every one should make a resolve that he will face calmly whatever happens in this year, accepting it with good grace and welcoming everything. Consider everything as for one's own good. Men should rise above sorrow and happiness, success and failure. This is the primary message of the Ugadi festival.


In Andhra Pradesh, eatables such as "Pulihora", "Bobbatlu" and preparations made with raw mango go well with the occasion. In Karnataka too, similar preparations are made but called "Puliogure" and "Holige". The Maharashtrians make "Puran Poli" or sweet 'Rotis'.


Kavi Sammelanam:Kavi Sammelanam or poetry recitation is a typical Telugu Ugadi feature. Ugadi is also a time when people look forward to a literary feast in the form of Kavi Sammelanam. Many poets come up with new poems written on subjects ranging from Ugadi to politics to modern trends and lifestyles.


Ugadi Kavi Sammelanam is also a launch pad for new and budding poets. It is generally carried live on All India Radio, Hyderabad and the Doordarshan - Hyderabad, following "Panchangasravanam" (New year calendar) narrating the way the New Year would shape up in the lives of people and the state in general. 'Kavis' or poets of many hues - political, comic, satirical reformist, literary and melancholic make an appearance on the Ugadi stage.


Ugadi is thus a festival of many shades. It ushers in the New Year, brings a rich bounce of flora and fills the hearts of people with joy and contentment.

Thursday, March 11, 2010

Get free wireless internet access

This post explains about how can you get a free wireless internet access. If you live in a very big apartment chances are, people have internet access and some of them even have wireless connection. So it is possible for you to connect and use their wireless internet on your mobile devices live laptops, mobile phones and even i-pod touch.


I'm not talking a techie or geeky stuff, there is a software called Easy Wifi Radar which does it easily.

Download this software from here http://www.makayama.com/easywifiradar.html. After you download just go through the easy installation. Then open the software and let it do the work automatically. When you get a connection just open your internet browser. Go ahead and download this software.

Enjoy!!

Guruji.com Music Search - The easiest and fastest way to your favorite song

1) Have you ever tried looking for your favorite song and gotten disappointed?


2) Have you ever complained about not having a one stop shop for online music?

3) Did you ever wish a search engine solved these problems for you, at least for Indian music?

If the answer to at least one question above is yes, read on.

Guruji Music Search – Guruji Music Search is a one stop shop for all Music lovers searching for Music on the Web. Our Music Index (enriched by songs crawled from all over from the web) has songs ranging from 1932 till 2008, across languages. Guruji Music Search is an attempt to allow users to search for songs in the fastest and easiest way possible. You can search for a song by the song’s words, singers, movie/album, actors, music directors and so on…

One can use the “usual” queries (like by Movie or by Song) to search for the song –


Taare Zameen Par

Rang De Basanti

Or go for some specific queries like –

Dilip+Kumar+Laxmikant+Pyarelal+1986 (Songs featuring Dilip Kumar

with music by Laxmikant Pyarelal and released in 1986)

Couldn’t guess the movie of the song? – Karma.

You can also refine your results on parameters like – Language, Time and whether the word occurs in Song, Movie/Album Title, Singer, Actor and so on.

For example the search query “Kishore Kumar”, the user can refine for –

1. Languages – Hindi, Bengali, Marathi (Languages in which Kishore Kumar has sung)

2. Time – 1971-1975, 1981-1985, 1976-1980, 2006-2008, 1956-1960

3. Category – Kishore Kumar as Singer, Actor, Composer

Do try it out and let us know what you thought.

Guruji Music Search, coz everybody needs a little music in life!

Also available in all South Indian languages including Telugu......So,What are you waiting for?.........Get into music.guruji.com

Buy a Cell Phone Battery @ Rs.9

Look at this picture!

This is FrvrOn V-G2300, recently launched by Olive Telecommunications. FrvrOn V-G2300 Dual Sim mobile phone is compatible with any AAA battery which you can buy from your nearest local shop. This phone is priced at MRP of Rs. 1699 and will be available in India.


 Key Features FrvrOn V-G2300

Platform ULC2 7800


Dimensions 103x44x18.0

Screen Size 1.5” CSTN Color

Screen Resolution 128x128

Preloaded Games

Alarm

Calculator

Calendar

Speaker Phone

2 Indian women in Forbes ultra-rich list

Two Indian women including Savitri Jindal and Indu Jain have been named among the list of world's top billionaires compiled by the US magazine Forbes.


Jindal with a net worth of $12.2 billion has been ranked at 44th place in the global list, while Bennett, Coleman & Co's chairperson Indu Jain at $2.8 billion comes at 354th rank.

Jindal, the non-executive chairperson of, steel and power conglomerate, OP Jindal Group, is the fifth richest woman in the world.

Retail chain major Wal-Mart's Christy Walton is world's richest woman with a net worth of $22.5 billion, placed at the 12th position in the overall list led by Mexican billionaire Carlos Slim, with a fortune of $53.5 billion.

Walmart's Alice Walton follows as the second richest women in the list with a networth of $20.6 billion at the 16th place.

Walton is followed by L'Oreal heiress Liliane Bettencourt (with networth of $20 billion), Swedish packaging giant Tetra Laval's Birgit Rausing & family ($13 billion), and Savitri Jindal ($12.2 billion).

The Forbes list of 1,011 billionaires includes 89 women from across the globe. From India, there are just two women and 48 men.

Indian industrialist Mukesh Ambani has been named as the richest Indian and fourth richest person globally with a networth of $29 billion.

Forbes rich list: India's wealthiest people

Traditionally dominated by Americans and Europeans, the 2010 Forbes list of world's billionaires released on Wednesday has thrown up many surprises including Mexican telecoms tycoon Carlos Slim grabbing the top slot.


According to Forbes, Asian billionaires increased their wealth as the region’s rich expanded their fortunes at the world’s quickest pace in the past year. Forbes said the list reflect the increasing presence of developing nations.

Reliance Industries (RIL) Chairman Mukesh Ambani and steel czar Lakshmi Mittal have figured in the top 10 on the 2010 Forbes list of world's billionaires.

With China and India leading the way, the number of Asian billionaires increased to 234 from 130 a year earlier, Forbes said.

Following is the Forbes list of top 25 richest people in India.


Rank -- Name -- Net Worth (in $ bln)

4 Mukesh Ambani $29.0

5 Lakshmi Mittal $28.7

28 Azim Premji $17.0

36 Anil Ambani $13.7

40 Shashi & Ravi Ruia $13

44 Savitri Jindal $12.2

74 K P Singh $9.0

86 Kumar Birla $7.9

87 Sunil Mittal $7.8

113 Anil Agarwal $6.4

148 Adi Godrej &family $5.2

167 Gautam Adani $4.8

173 Dilip Shanghvi $4.6

201 Shiv Nadar $4.2

297 G M Rao $3.2

297 Malvinder & Shivinder Singh $3.2

316 Uday Kotak $3.0

342 Kalanithi Maran $2.9

354 Subhash Chandra $2.8

354 Micky Jagtiani $2.8

354 Indu Jain $2.8

463 Sudhir & Samir Mehta $2.1

488 Yusuf Hamid & family $2.0

488 Cyrus Poonawalla $2.0

488 Rajan Raheja $2.0.

Forbes releases billionaires ’10 list

Forbes has released its 2010 list of Billionaires. There at least two Indians in the top five list and the richest man is no longer Bill Gates.

The veterans Bill Gates and Warren Buffet have made way for Mexican telecom tycoon, Carlos Slim Helu, at the top spot with a networth of $53.5 billion, pushing Gates and Buffet to runner up positions at rank 2 and 3 respectively.


Cashing in at 4 and 5 are none other than fellow Indians, Mukesh Ambani and Laxmi Mittal.

Mukesh Ambani has bagged the 4th spot with a networth of a massive $29 billion as compared to last years 7th place and $19.5 billion dollar networth.

Steel tycoon Laxmi Mittal has also moved up from being ranked 8th to round off this years top 5 with networth of $28.7 billion as against last years $19.3 billion.

India has prominently featured in the list this year as compared to last with a total of six Indians in the top 50 as compared to only the Ambani brothers and Laxmi Mittal being listed last year.

India has also clocked a massive $113.6 billion put together, making the $48.8 billion networth of the three individuals last year look like a measly sum.

Azim Premji has joined the elite 50 in the 28th position with $17 billion. But Mukesh's younger brother Anil Ambani slipped two places down from the 34th rank last year to 36th this year with his networth standing at $13.7 billion.

Essar brothers, Shashi and Ravi Ruia come in at 40th with $13 billion and rounding up India's standing in the top fifty is Savitri Jindal with $12 billion networth.

With the India growth story back on track and Indian business making its presence felt in the global arena, the Forbes listing reflects the rise and rise of the Asian tiger

Bill Gates No Longer World's Richest Man

Carlos Slim Helu takes No. 1 spot on Forbes World's Billionaires list as a record 164 10-figure titans return to the ranking amid the global economic recovery.


For the third time in three years, the world has a new richest man.

Riding surging prices of his various telecom holdings, including giant mobile outfit America Movil ( AMX - news - people ), Mexican tycoon Carlos Slim Helu has beaten out Americans Bill Gates and Warren Buffett to become the wealthiest person on earth and nab the top spot on the 2010 Forbes list of the World's Billionaires.

Slim's fortune has swelled to an estimated $53.5 billion, up $18.5 billion in 12 months. Shares of America Movil, of which Slim owns a $23 billion stake, were up 35% in a year.

That massive hoard of scratch puts him ahead of Microsoft ( MSFT - news - people ) cofounder Bill Gates, who had held the title of world's richest 14 of the past 15 years.


Gates, now worth $53 billion, is ranked second in the world. He is up $13 billion from a year ago as shares of Microsoft rose 50% in 12 months. Gates' holdings in his personal investment vehicle Cascade ( CAE - news - people ) also soared with the rest of the markets.

Buffett's fortune jumped $10 billion to $47 billion on rising shares of Berkshire Hathaway ( BRK - news - people ). He ranks third.

The Oracle of Omaha shrewdly invested $5 billion in Goldman Sachs ( GS - news - people ) and $3 billion in General Electric ( GE - news - people ) amid the 2008 market collapse. He also recently acquired railroad giant Burlington Northern Santa Fe ( BNI - news - people ) for $26 billion.

In his annual shareholder letter Buffett wrote, "We've put a lot of money to work during the chaos of the last two years. When it's raining gold, reach for a bucket, not a thimble."

Many plutocrats did just that. Indeed, last year's wealth wasteland has become a billionaire bonanza. Most of the richest people on the planet have seen their fortunes soar in the past year.

Wednesday, March 10, 2010

Notable People Who Dropped Out of School

Everyone knows how important it is to stay in school, get a good education, and graduate with a diploma. But it may be hard to stay focused after reading about the success of these famous dropouts. Hard work, drive, natural talent, and sheer luck helped them overcome their lack of education, but many still returned to school later in life.

In this article, you will learn about notable people including inventors, politicians, and entertainers who dropped out of school before their rise to fame.

1. Thomas Edison Thomas Edison is probably the most famous and productive inventor of all time, with more than 1,000 patents in his name, including the electric light bulb, phonograph, and motion picture camera. He became a self-made multimillionaire and won a Congressional Gold Medal. Edison got a late start in his schooling following an illness, and, as a result, his mind often wandered, prompting one of his teachers to call him "addled." He dropped out after only three months of formal education. Luckily, his mother had been a schoolteacher in Canada and home-schooled young Edison.

2. Benjamin Franklin

Benjamin Franklin wore many hats: politician, diplomat, author, printer, publisher, scientist, inventor, founding father, and coauthor and cosigner of the Declaration of Independence. One thing he was not was a high school graduate. Franklin was the fifteenth child and youngest son in a family of 20. He spent two years at the Boston Latin School before dropping out at age ten and going to work for his father, and then his brother, as a printer.

3. Bill Gates


Bill Gates is a co-founder of the software giant Microsoft and has been ranked the richest person in the world for a number of years. Gates dropped out of Harvard in his junior year after reading an article about the Altair microcomputer in Popular Electronics magazine. He and his friend Paul Allen formed Micro Soft (later changed to Microsoft) to write software for the Altair.

4. Albert Einstein


Although he was named Time magazine's "Man of the Century," Albert Einstein was not an "Einstein" in school. The Nobel Prize-winning physicist, famous for his theory of relativity and contributions to quantum theory and statistical mechanics, dropped out of high school at age 15. Deciding to continue his education a year later, Einstein took the entrance exam to the prestigious Swiss Federal Institute of Technology, but failed. He returned to high school, got his diploma, and then passed the university's entrance exam on his second attempt.


5. John D. Rockefeller


Two months before his high school graduation, history's first recorded billionaire, John D. Rockefeller, Sr., dropped out to take business courses at Folsom Mercantile College. He founded the Standard Oil Company in 1870, made his billions before the company was broken up by the government for being a monopoly, and spent his last 40 years giving away his riches, primarily to causes related to health and education. Ironically, this high school dropout helped millions get a good education.

6. Walt Disney


In 1918, while still in high school, future Oscar-winning film producer and theme park pioneer Walt Disney began taking night courses at the Academy of Fine Arts in Chicago. Disney dropped out of high school at age 16 to join the army, but because he was too young to enlist, he joined the Red Cross with a forged birth certificate instead. Disney was sent to France where he drove an ambulance that was covered from top to bottom with cartoons that eventually became his film characters. After becoming the multimillionaire founder of the Walt Disney Company and winning the Presidential Medal of Freedom, Disney received an honorary high school diploma at age 58.

7. Richard Branson


Britain's Sir Richard Branson is a self-made billionaire businessman. He founded Virgin Atlantic Airways, Virgin Records, Virgin Mobile, and most recently, a space tourism company to provide suborbital trips into space for anyone who can afford them. Suffering from dyslexia, Branson was a poor student, so he quit school at age 16 and moved to London, where he began his first successful entrepreneurial activity, publishing Student magazine.

Nucleotide BLAST

Nucleotide BLAST refers to the use of a member of the BLAST suite of programs, such as “blastn” to search with a nucleotide “query” against a database of nucleotide “subject” sequences.


Available Nucleotide-Level Searches

There are two members of the BLAST suite of programs that are designed to make nucleotide-to-nucleotide alignments. The first is the original BLAST nucleotide search program known as “blastn.” The “blastn” program is a general purpose nucleotide search and alignment program that is sensitive and can be used to align tRNA or rRNA sequences as well as mRNA or genomic DNA sequences containing a mix of coding and noncoding regions. A more recently developed nucleotide-level BLAST program called MegaBLAST (7) is about 10 times faster than “blastn” but is designed to align sequences that are nearly identical, differing by only a few percent from one another. MegaBLAST allows the rapid mapping of a transcript onto a typical 3 billion base mammalian genome in seconds, and is useful for processing large batches of sequences. A refinement of MegaBLAST, known as discontiguous MegaBLAST, uses a discontiguous template to define an initial “word” in which characters in some positions, such as those in the wobble base position of codons, need not match. Discontiguous MegaBLAST allows rapid cross-species mappings involving coding regions in cases where species differences in codon usage would prevent alignments using the original MegaBLAST program.



Examples of Nucleotide BLAST Searches

Problem 1

Click on the link indicated by “P” next to the “Nucleotide-nucleotide BLAST (blastn)” to access the problem. This problem demonstrates how to use BLAST to find human sequences in GenBank that can be amplified with a particular primer pair. Access the nucleotide–nucleotide BLAST page (by clicking on the Nucleotide–nucleotide BLAST link). Paste both the forward and reverse primers into the BLAST input box. Insert a string of about 30 N’s after the first primer sequence to separate the two sequences to be found in separate, not overlapping alignments. Limit your search to human sequences by selecting “Homo sapiens” from the “All organisms” pull down menu under the Options for advanced blasting and click the BLAST! link. Retrieve results by clicking on the “Format” button. Look for two hits to the same database sequence.



In this result, shown in Fig. 1, there are 13 GenBank entries that align to both the forward and reverse primers at different locations (indicated by thick bars) with a gap in between (indicated by a thin gray bar). There are two GenBank entries that align only to the reverse primer. One alignment of the primer pair to the GenBank entry L78833.1 is shown in Fig. 2. The forward primer aligns to the sequence L78833.1 on the forward strand (as indicated by Strand Plus/Plus) at nucleotides 3252..3270. The reverse primer aligns to the reverse strand (as indicated by Strand Plus/Minus) at nucleotides 3475..3457. Thus, the two primers will amplify the sequence from nucleotides 3252..3475 of the entry L78833.1. Retrieve the entry L78833.1 in Entrez, by clicking on it. The annotation shows that the amplified region covers the Exon 1a and the upstream sequence of the BRCA1 gene. Refer to the Note 1 for the multiple hits. You may perform similar search against the human genome BLAST database.

Saturday, March 6, 2010

DNA Looping and Gene Expression

DNA looping is exactly that - the DNA molecule actually forms loops. These loops are created by proteins and protein complexes binding to different regions of the DNA structure. The proteins interact with each other and this causes loops to form. DNA looping is involved in many cellular processes such as transcription, recombination, gene expression, and replication. The neat thing about DNA looping is that when loops form in the DNA structure proteins that are bound some distance away from the genes they control can be brought to the promoter region by looping the intervening DNA.


Types of DNA Looping

There are two different types of DNA looping. The classification comes from the physical forces that control their formation:

1) Short or energetic - for DNA ~150 bp elasticity is the dominant force, and the bending and twisting of DNA is important, as is the elastic properties of the molecules that tie the loop.

2) Long or entropic - what is key is the motion of the DNA regions in the cell before they find each other.


DNA Looping Uses:

DNA looping plays many important roles in the life of a cell. By bringing two DNA regions together DNA loops enable the transfer of genetic information during recombination; they also tie the ends of chromosomes, and regulate the length of telomeres.

It is therefore a safe bet to assume that many malfunctions that occur in our bodies will be down to faults in the DNA looping process. So the more that is known about how DNA loops make sure gene expression goes off without a hitch, and the right gene is turned on - the better our chances of being able to fix things when they go wrong.

Understanding DNA looping is a burgeoning research endeavour, especially as some diseases, including cancers are caused or made worse by incorrect looping and errors in gene expression

Friday, March 5, 2010

Technology Education

Future technology education programs will be mind-blowing compared to what we have today. Technology education in the future will rely heavily on input learning and virtual reality experiential reenactment.

One of the benefits of future technology education is that people will finally be cloned. Of course moral objections will still remain in some countries like the U. S. but other countries will clone human beings for various reasons, like high IQ, pedigree, athletics and other reasons.


It will be clear in the future that cloned human beings do have a soul and the "soul splitting" or "soul fragmentation" theory will take root. This theory will basically say there are a limited number of souls and too many bodies, so when people die and more are reborn, souls split among many different human beings. This is why finding one's "soul mate" or "soul mates" will be increasingly important to people.

Future technology education will rely on wireless input into one's brain. Downloads of a plethora of textual information will be quickly transported via computer into the heads of students. Distance learning will be common. As well photographic memories for humans will be developed by future medical science.

But this "book learning" of the technology education will be no substitute for experiential learning. This is why virtual reality will play such an important role in the future of technology education.

For years, pilots have known the value of a flight simulator in order to practice take-offs, landings and other flying maneuvers. Video games for young people will lead to jobs in flying drones and doing other distance mechanical, robotic and aeronautical jobs.

But, this will be taken a step further in technology education. Students with the fear of public speaking will be able to practice delivering oral papers and calming themselves in front of a virtual setting.

Teachers will practice in front of virtual classrooms. Those doing technical repairs will also practice in a real life virtual simulation. First responders will be put inside virtual practice fields as will soldiers like stepping inside a video game. No longer will Tron or Total Recall be precursor movies that glimpse the future, but relics of the past.

The combination of this downloaded wireless textual information into one's brain and the virtual reality experiential training will be powerful technology educational devices that may be updated often to keep students and employees engaged in the latest happenings in their fields. No more conference calls and Powerpoint presentations.

Paradigm shifts and disruptive technology will be the norm in the future. Neural networks of computers will mean that both humans and non-humans will be learning at a rapid pace never seen before in the history of mankind.

In the virtual worlds I had previously talked of there will be mentors, guides and teachers combining to help students achieve high academic standards in their technology education program. Some of these will be programmed in while others will be human walk-ons into the virtual scenarios.

In technology education a few years from now, learning disabilities will be a thing of the past, partly due to advances in medical science that will prevent many cases through genetic alterations and for those few who are left, virtual and downloadable textual programs specific to each child's development, plus mentors, aids and teachers will not only strengthen the deficits but also develop the technological educational assets the child may already be endowed with.

Technology education many years from now won't be limited by geographical location. Students may learn the latest German, Japanese or Brazilian technical theories with either translations or by quickly learning a new language via the methods already described.

In the future, social media will have taken over and not just for talking to friends but for chatting with other students and colleagues. Most of these chats will take place by stepping into and out of virtual chat rooms. Wireless "brain alerts" will be given so that students know what chats are taking place at all times and choose to join or not to join at will.

Sleep, while still important will be condensed, focused and an intense experience so that both mind and body can consolidate images, thoughts, feelings (and relaxation) of the day and of the past. Future technology education will help psychiatrists and psychotherapists deal with patients who have experienced trauma, past, present or future.

Psychiatrists will already have the full DNA and genome structure of each patient before he or she walks into his virtual office. Prescribing pharmaceuticals will that will be highly targeted will be the norm. As for psychologists, future technology education will allow them to access and assess areas of trauma, resistance and denial quickly and use one of many psychological templates in dealing with emotional issues. The pain of grief, while not eliminated, will be a far shortened process.

This is just a glimpse into the new education technology of the future. Many other advances will be made that will shift the way we think and learn. The world as we know it will be more fluid, more science and technology based, less political and more about helping mankind solve problems of co-existence.

Thursday, March 4, 2010

India among top 5 government funders of neglected diseases

India along with Brazil are now in the top 5 government funders of neglected disease R&D and are taking the lead on diseases like leprosy and dengue fever. An annual survey of investment into neglected disease R&D released, shows that nearly $2.96 billion was spent on making new products for neglected diseases in 2008. A key finding of the G-FINDER survey was that, for some diseases, traditional donor funding is being replaced by investment from pharmaceutical companies and Innovative Developing Countries (IDCs) such as Brazil, India and South Africa. Where there is no profitable market, as with many of the diseases that affect sub Saharan Africa, R&D remains heavily reliant on traditional donor and philanthropic funding


“These are tough economic times but, for the first time, we are seeing that for some neglected diseases the traditional reliance on charitable funding and donor aid is being replaced by a market and domestically driven R&D,” said report author, Dr Mary Moran of The George Institute for International Health. “This is good news for new medicines and diagnostics in India, Brazil and South Africa, but not for most of sub Saharan Africa where there is still no market and they will have to rely on donors and philanthropists for some time yet,” she added.

This trend reflects the growing research strength and pharmaceutical markets of India and Brazil, in particular, as well as high local incidence of diseases such as leprosy and dengue. The downside of this trend is that diseases of Africa continue to rely on donors, who still provide more than 85 percent of funds for Buruli ulcer, trachoma, kinetoplastid diseases like sleeping sickness and many helminth infections.


Report Findings


The G-FINDER report shows that in 2008 Innovative Developing Countries (IDC`s) like India, Brazil and South Africa and pharmaceutical companies funded:

1.Nearly 60 percent of R&D for pneumonia and meningitis


2.More than half (51 percent) of leprosy R&D (Brazil and India have the largest number of new leprosy cases per year in the world)


3.Nearly half (46 percent) of R&D for new dengue products (the Americas, particularly Brazil, along with Asia, have the highest global prevalence of dengue)


4.Around 20 percent of funding for new treatments and vaccines for diarrhoeal illnesses, TB and malaria (which occur worldwide)

“The G-Finder survey report has put India as the 5th largest public funder of neglected diseases, and ICMR provides 60 percent of the funds. Visceral leishmaniasis and leprosy are amongst most neglected diseases, and we must further improve our funding for research to find new tools to combat them,” said Dr V M Katoch, Secretary, Department of Health Research, and Director-General, Indian Council of Medical Research, New Delhi.


Other Key Findings


•Global funding for neglected disease R&D ground to a standstill in 2008, with funding cuts or freezes across the board including a $26.3 million decrease in funding from High-Income Countries (HICs)

•This injection of additional funds led to a net increase of $100.1m (3.9 percent) in global neglected disease R&D investment in 2008.

•Two organizations provided nearly 60 percent of global funding in this area in 2008: the US National Institutes of Health ($1.1 billion, 36.5 percent) and the Gates Foundation ($617 million, 20.9 percent).

•The pharmaceutical industry was collectively the third largest global investor, with companies providing one-eighth ($365 million, 12.4 percent) of global funding for neglected disease R&D.

"This G-Finder report confirms the welcome news that an increasing number of Pharma companies are allocating R+D resources to the neglected diseases surveyed. Although no major financial returns can be expected with medicines for many of these diseases in the foreseeable future, there is a growing sense of responsibility for underprivileged patients and reputational aspects,which are helping to improve the lives of patients”, said Prof Paul L Herrling, Head of Corporate Research for Novartis International.

Budget 2010 to boost research

Bangalore, Mar 03, 2010: Over the years, the finance ministry has given the life sciences industry due emphasis in budget. With India figuring low on various healthcare counts, increased allocation in healthcare shows the government’s commitment to tackle the situation.



Through the budget 2010, Finance Minister Pranab Mukherjee has proposed to extend the scope of weighted deduction on expenditure incurred on in-house Research and Development to 200 percent from 150 percent, to be effective upto 2012. Mukherjee has also proposed to increase the weighted deduction on payments made to national laboratories and research organizations for scientific research from 125 percent to 175 percent. But at the same time increase in MAT to 18 percent from 15 percent and input duty on raw materials from 8 to 10 percent has made the industry unhappy.


Reacting to the budget Sanjay Nagrath, Chief Financial Officer, Intas Biopharmaceuticals says, “It is a welcome move from Finance Minister to raise weighted deduction on in–house R&D expenditure from 150 percent to 200 percent and weighted deduction on payment made to national laboratories research association, colleges, and other institutions for scientific research is increased to 175 percent from 125 percent. Reduction in excise duty on goods covered under the Medicinal and Toilet preparation Act from 16 percent to 10 percent is also a positive move.”


"GST (Goods & Services Tax) implementation from April 2011 was expected however it is important that the government ensures timely implementation”, he said.


Commenting on the weighted R&D deduction, Satish Reddy, Managing Director and COO, Dr. Reddy’s Laboratories said, “From the pharmaceutical sector perspective, which is an innovation driven industry, increase in weighted deduction on expenditure incurred on in-house R&D is a positive and encouraging move.


“The Government’s commitment to ensure continued growth of Special Economic Zones augurs well for industrial development. While we await the fine print on specifics and implementation proposal, the aim to implement GST and DTC by April 2011 is a welcome move, he adds.


Praveen Gupta, VP-Business Development, Premas Biotech echoed the same point,“The increase in allocation of fundings for biotech R&D has been a great step which will boost the research into some major areas. But he lamented at the fact that nothing has been done on the import duty which according to him is a major bottleneck in the competition at global scale.


In addition, the industry is almost unanimous in claiming that the benefits, which would accrue from this incentive, would be more than neutralized by the increase in MAT to 18 percent from 15 percent . The industry had requested that the last year's MAT hike from 10 percent to 15 percent be reversed in this budget, however the industry feels disappointed as this was not done.


“The increase in the MAT rate is a negative step for industry as it will increase tax burden on the MAT paying companies,” says Sanjay of Intas Biopharmaceuticals.


Satish opines, “Reduction in corporate surcharge will provide marginal relief while the MAT rate increase, which is likely to balance out the benefits, could have been avoided.”


The 2010 budget may prove to be a mixed bag for life sciences sector as well as patients, with prices of medicines going up marginally by 1-2 percent, while concessions given to medical, surgical, dental equipment and ortho-paedic implants leading to reduction in prices.


Industry feels that prices may be increased on account of higher raw material costs due to the two percent excise duty rollback. But concessions given to medical equipment, and exemptions of custom duty on inputs for manufacture of orthopedic implants should lead to a reduction in prices of these devices. Also, if certain parts are imported for manufacture of equipment in India, no CVD and SAD will be levied and only five percent basic customs duty will apply.


Gautam Khanna, Executive Director - Healthcare Business, 3M India comments, “A concession of basic duty on the manufacture of parts and accessories of medical equipments is a welcome move. Also, full exemption on medical equipments will help manufacturers make it available for end users at a better price.”


He further comments, “Increase in healthcare budget allocation is going to be a welcome change as it will help boost public health, insurance and infrastructure. This will hopefully see a potential increase in the penetration of health insurance in India and the move is expected to have a direct positive impact on the demand and quality of healthcare services in India.”


V Raja, President and CEO, GE Healthcare South Asia says, “While the budget is a very balanced one, we would have been happier if infrastructure status was granted to the healthcare industry. Healthcare industry is one of the largest and most critical one for healthy people, healthy country and a healthy economy. Infrastructure status would have helped healthcare industry to have access to more funds, more benefits and thus resulted in increased and affordable healthcare to the masses. “


Overall the industry was not really enthused with this years' budget and termed the steps announced not enough to give the necessary boost to the sector. The industry was also expecting an increase in healthcare infrastructure, with creation of focused SEZs and tax holiday on exports, which remained unaddressed.